Comparison of Total Serum Sulfhydryl and Glutathione S Transferase Activities in Patients with Oral Cavity Malignancies and Healthy Control Individuals

Belli Ş., Demir H., Özdemir B., Demir C.

International Journal of Academic Medicine and Pharmacy, vol.2, no.2, pp.72-75, 2020 (Peer-Reviewed Journal)


Serum glutathione S transferase is one of the enzymatic antioxidants that play an important role in cell protection against oxidant stress. Serum sulfhydryl level is among the non-enzymatic antioxidant products that play a crucial role in scavenging of elevated reactive oxygen species produced as a result of deterioration in oxidative stress homeostasis. We were examined the changes in these two mechanisms of activity enzyme some antioxidant (Serum glutathione S transferase and serum total sulfhydryl) in patients with oral cavity malignancy. Forty-five people were included in the study. The patient group consisted of 20 (5 female, 15 male), control group 25 (6 female, 19 male, healthy individuals who were recruited from ear-nose-throat outpatient clinic). Serum glutathione S transferase activity and total sulfhydryl level were measured by spectrophotometric method. The mean value of glutathione S transferase (0.005±0.002 nmol/l) in the study group was found to be significantly lower than the control group (0.046±0.007 nmol/l) (p=0.0001). The mean value of total sulfhydryl in the study group (0.344±0.350 mmol/l) was significantly lower than the control group (2.002±0.271 mmol/l) (p=0.0001). Glutathione S transferase activity and total sulfhydryl level that play a role in defending against the reactive oxygen species are among the important and promising parameters which can be used in the follow-up of cancer patients, in the selection of treatment modalities and in cancer research. As a result, glutathione S transferase and total sulfhydryl may be a marker in oral cavity cancers.