Affinity to some inhibitors of human carbonic anhydrase-1 and bovine carbonic anhydrase


Arslan O., Kufrevioglu O.

JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-ENVIRONMENTAL SCIENCE AND ENGINEERING & TOXIC AND HAZARDOUS SUBSTANCE CONTROL, cilt.31, ss.2017-2022, 1996 (SCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 31 Konu: 8
  • Basım Tarihi: 1996
  • Doi Numarası: 10.1080/10934529609376471
  • Dergi Adı: JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-ENVIRONMENTAL SCIENCE AND ENGINEERING & TOXIC AND HAZARDOUS SUBSTANCE CONTROL
  • Sayfa Sayıları: ss.2017-2022

Özet

The carbonic anhydrase Isoenzymes employed here have been purifield in high yields by affinity chromatograpy using different affinity gels(Sepharose4B-L-tyrosine-Benzensulfonamide). Inhibition effect of 2-Substituted-1,3,4-Thiadiazole-5-Sulfonamides on human carbonic anhydrase-I (HCA-I) and bovine carbonic anhydrase (BCA) have been determined. It was found that inhibition effects of these compounds on BCA and CA-I were very great.