Electrochemical and analytical performance of cathodically pretreated boron-doped diamond electrode for the determination of oxazolidinone antibiotic linezolid in cationic surfactant media

Pınar P. T., Şentürk Z.

JOURNAL OF ELECTROANALYTICAL CHEMISTRY, vol.878, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 878
  • Publication Date: 2020
  • Doi Number: 10.1016/j.jelechem.2020.114681
  • Journal Name: JOURNAL OF ELECTROANALYTICAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chimica, Compendex, INSPEC
  • Keywords: Linezolid, Boron-doped diamond electrode, Cathodic pretreatment, Square-wave voltammetry, Cationic surfactant, Drug analysis, VOLTAMMETRIC DETERMINATION, PHARMACEUTICALS, STABILITY, OXIDATION, DRUGS
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

The electrochemical oxidation of an oxazolidinone class of antibiotic, Linezolid (LNZ) was studied in aqueous as well as aqueous/surfactant media on a commercially available boron-doped diamond (BDD) electrode pretreated cathodically. By using cyclic voltammetry, LNZ showed two couples of oxidation/reduction peak in aqueous solutions. The electrode process is pH-dependent and controlled by diffusion. The compound yielded two well-separated oxidation steps in acidic, neutral and alkaline media by employing square-wave voltammetry. The sensitivity of the voltammetric measurements was improved when the cationic surfactant, cetyltrimethylammonium bromide (CTAB) was present in the electrolyte solution at pH 4.0. In Britton-Robinson buffer containing 0.9 mM CTAB, the calibration curves were linear for both oxidation peaks (Ia and IIa) over concentration ranges of 0.25-6.41 mu g mL(-1) (0.74-19.27 mu M), with detection limits of 0.05 mu g mL(-1) (0.15 mu M) for Ia, and 0.12 mu g mL(-1) (0.34 mu M) for IIa. The practical applicability of developed methodology was tested in pharmaceutical formulations.