JOURNAL OF ELECTROANALYTICAL CHEMISTRY, vol.878, 2020 (SCI-Expanded)
The electrochemical oxidation of an oxazolidinone class of antibiotic, Linezolid (LNZ) was studied in aqueous as well as aqueous/surfactant media on a commercially available boron-doped diamond (BDD) electrode pretreated cathodically. By using cyclic voltammetry, LNZ showed two couples of oxidation/reduction peak in aqueous solutions. The electrode process is pH-dependent and controlled by diffusion. The compound yielded two well-separated oxidation steps in acidic, neutral and alkaline media by employing square-wave voltammetry. The sensitivity of the voltammetric measurements was improved when the cationic surfactant, cetyltrimethylammonium bromide (CTAB) was present in the electrolyte solution at pH 4.0. In Britton-Robinson buffer containing 0.9 mM CTAB, the calibration curves were linear for both oxidation peaks (Ia and IIa) over concentration ranges of 0.25-6.41 mu g mL(-1) (0.74-19.27 mu M), with detection limits of 0.05 mu g mL(-1) (0.15 mu M) for Ia, and 0.12 mu g mL(-1) (0.34 mu M) for IIa. The practical applicability of developed methodology was tested in pharmaceutical formulations.