Synthesis and biological evaluation of quinoline-triazole and quinolone-triazole conjugates


Gümüş A. , OKUMUŞ V.

TURKISH JOURNAL OF CHEMISTRY, cilt.42, ss.1344-1357, 2018 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 42 Konu: 5
  • Basım Tarihi: 2018
  • Doi Numarası: 10.3906/kim-1804-18
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Sayfa Sayıları: ss.1344-1357

Özet

One-pot synthesis of novel quinoline- and quinolone-substituted 1,2,3-triazoles has been performed from the key intermediates, quinoline- and quinolone-substituted propargyl derivatives 1-3 (48%-88% yields). The antioxidant properties of the newly synthesized compounds, 1a-1c, 2a-2c, and 3a-3c, were evaluated by monitoring DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging abilities, metal chelating effects, and reducing power. The scavenging effects of compounds on the free radical decreased in the order of 3b > 3a > 1b and were found to be 36.3%, 34.9%, and 27.6% at the concentration of 500 mu g/mL, respectively. All of the compounds showed low chelating capacity. Furthermore, the antibacterial activity was studied against gram-positive and gram-negative bacteria and the DNA binding ability of the compounds was evaluated with calf thymus DNA using agarose gel electrophoresis.