THE EFFECT OF RESVERATROL TREATMENT ON HEART RATE AND QT VALUES IN RATS WITH CHRONIC FLUOROSIS

Bulduk B., Oto G., Özdemir H., Günbatar N., Koçak Y., Gül C., ...More

FRESENIUS ENVIRONMENTAL BULLETIN, vol.31, no.6, pp.5731-5735, 2022 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 6
  • Publication Date: 2022
  • Journal Name: FRESENIUS ENVIRONMENTAL BULLETIN
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Aerospace Database, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), CAB Abstracts, Chemical Abstracts Core, Communication Abstracts, Environment Index, Geobase, Greenfile, Metadex, Pollution Abstracts, Veterinary Science Database, Civil Engineering Abstracts
  • Page Numbers: pp.5731-5735
  • Keywords: Fluorosis, Resveratrol, ECG, ELECTROCARDIOGRAM, POLYPHENOL, WINE
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

With this study, it was investigated how the impact of sodium fluoride (NaF) exposure on the cardiac conduction system would be treated with resveratrol. A total of 8 rats, 4 female and 4 male, weighing 200-300 grams, were used in each group. The first group was separated as the control group. The second group was determined as the group given 10 melt/day NaF, the third group as the group given 50 mg/It/day resveratrol, and the fourth group as the group given 10 mg/It/day NaF + 50 mg/It/day resveratrol. In the study conducted for 12 weeks, resveratrol and NaF were mixed into the drinking water of rats. When the study was finished after 4 months, the rats were anesthetized. They were placed in the right lateral position for the recording of ECGs. ECG samples were evaluated in II. derivation. Heart rate numbers were found high and QT values were found low in the groups that were administered only NaF. The heart rate and QT values of the groups administered with resveratrol alone or in combination with NaF showed parallelism with the control group.