Synthesis and some reactions of 4-(Ethoxycarbonyl)-1,5-Diphenyl-1H-pyrazole-3-carboxylic acid


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ŞENER A., Tozlu I. , Genc H. , Bildirici I. , ARISOY K.

JOURNAL OF HETEROCYCLIC CHEMISTRY, cilt.44, ss.1077-1081, 2007 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 44 Konu: 5
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1002/jhet.5570440516
  • Dergi Adı: JOURNAL OF HETEROCYCLIC CHEMISTRY
  • Sayfa Sayıları: ss.1077-1081

Özet

1,5-Diphenyl-1H-pyrazole-3,4-(dicarboxylic acid-4-ethyl ester 2, obtained from the 4-ethoxycarbonyl-5phenyl-2,3-furandione 1 and N-benzylidene-N'-phenyl hydrazine, was converted via reactions of its acid chloride 3 with various alcohols or N-nucleophiles into the corresponding ester 5 or amide derivatives 6, respectively. In addition, 2 was decarboxylated to give ethyl 1,5-diphenylpyrazole-4-carboxylate 4. Nitrile 7 derivative of 2 was also obtained by dehydration of 6a in a mixture of SOCl2 and DMF. While cyclo condensation reaction of 2 with hydrazine hydrate leads to the formation of pyrazolo[3,4d]pyridazine-4,7-dione 8, the reaction of 3 with anhydrous hydrazine provided a new bis pyrazole derivative 9.