A Simple Approach to Simultaneous Electroanalytical Quantification of Acetaminophen and Tramadol Using a Boron-doped Diamond Electrode in the Existence of Sodium Dodecyl Sulfate

Yunusoğlu O. , Allahverdiyeva S., Yardım Y. , Şentürk Z.

ELECTROANALYSIS, cilt.32, sa.2, ss.429-436, 2020 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Konu: 2
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1002/elan.201900452
  • Sayfa Sayıları: ss.429-436


The present work describes the individual, selective and simultaneous quantification of acetaminophen (ACP) and tramadol hydrochloride (TRA) using a modification-free boron-doped diamond (BDD) electrode. Cyclic voltammetric measurements revealed that the profile of the binary mixtures of ACP and TRA were manifested by two irreversible oxidation peaks at about +1.04 V (for ACP) and +1.61 V (for TRA) in Britton-Robinson (BR) buffer pH 3.0. TRA oxidation peak was significantly improved in the presence of anionic surfactant, sodium dodecyl sulfate (SDS), while ACP signal did not change. By employing square-wave stripping mode in BR buffer pH 3.0 containing 8x10(-4) mol L-1 SDS after 30 s accumulation under open-circuit voltage, the BDD electrode could be used for quantification of ACP and TRA simultaneously in the ranges 1.0-70 mu g mL(-1) (6.6x10(-6)-4.6x10(-4) mol L-1) and 1.0-70 mu g mL(-1) (3.3x10(-6)-2.3x10(-4) mol L-1), with detection limits of 0.11 mu g mL(-1) (7.3x10(-7) mol L-1) and 0.13 mu g mL(-1) (4.3x10(-7) mol L-1), respectively. The practical applicability of the proposed approach was tested for the individual and simultaneous quantification of ACP and/or TRA in the pharmaceutical dosage forms.