Serum prolidase activity, oxidative stress, and nitric oxide levels in patients with bladder cancer

Gecit I., Aslan M., Gunes M., PIRINCCI N., ESEN R., Demir H., ...More

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, vol.138, no.5, pp.739-743, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 138 Issue: 5
  • Publication Date: 2012
  • Doi Number: 10.1007/s00432-011-1136-4
  • Journal Name: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.739-743
  • Keywords: Bladder cancer, Nitric oxide, Total antioxidant status, Malondialdehyde, Prolidase activity, LIPID-PEROXIDATION, EXTRACELLULAR-MATRIX, COLLAGEN-METABOLISM, ANTIOXIDANT STATUS, CELL CARCINOMA, STOMACH-CANCER, BREAST-CANCER, VITAMIN-C, IMINODIPEPTIDURIA, INHIBITORS
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

Prolidase is a member of the matrix metalloproteinase family. It plays a major role in collagen turnover, matrix remodeling and cell growth. Nitric oxide (NO) regulates many processes such as collagen synthesis and matrix remodeling. Thus, NO may augment angiogenesis, tumor invasion, and metastasis. The aim of this study was to investigate total antioxidant status (TAS), malondialdehyde (MDA) and NO levels in patients with bladder cancer and to determine their relationship with prolidase activity.