Secondary Metabolites from Astragalus lycius and Their Cytotoxic Activities


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Horo I., Kocabas F., Alankus-Caliskan O., Özgökçe F. , Khan I. A. , BEDIR E.

NATURAL PRODUCT COMMUNICATIONS, cilt.11, ss.1847-1850, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 11 Konu: 12
  • Basım Tarihi: 2016
  • Dergi Adı: NATURAL PRODUCT COMMUNICATIONS
  • Sayfa Sayıları: ss.1847-1850

Özet

Eight known secondary metabolites were isolated from the methanolic extract of the whole plant of Astragalus lycius Boiss. They were identified as 5,5'-dihydroxy-3'-methoxy-isoflavone-7-O-beta-D-glucoside (1), genistin (2), sissotrin (3), 5,4'-dimethoxy-isoflavone-7-O-beta-D-glucopyranoside (4), (7S,8R)-5-methoxydehydrodiconiferyl alcohol-4-O-beta-D-glucopyranoside (5), 4-O-lariciresinol-glucoside (6), 2-phenylethyl-beta-D-glucopyranoside (7) and beta-isitosterol-3-O-beta-D-glucopyranoside (8) by spectroscopic methods including H-1- and C-13-NMR and HR-MS experiments, and by comparison with literature values. Compounds 1-7 are reported for the first time from Astragalus taxa. All of the compounds were tested for their cytotoxic activities against a number of cancer cell lines. Among them, only 6 exhibited significant activity against human colon carcinoma (HT-29) at 2.69 mu M concentration.

Eight known secondary metabolites were isolated from the methanolic extract of the whole plant of Astragalus lycius Boiss. They were identified as 5,5’dihydroxy-3’-methoxy-isoflavone-7-O? -D-glucoside (1), genistin (2), sissotrin (3), 5,4’-dimethoxy-isoflavone-7-O? -D-glucopyranoside (4), (7S,8R)-5methoxydehydrodiconiferyl alcohol-4-O? -D-glucopyranoside (5), 4-O-lariciresinol-glucoside (6), 2-phenylethyl? -D-glucopyranoside (7) and ? -sitosterol-3O-β-D-glucopyranoside (8) by spectroscopic methods including 1H- and 13C-NMR and HR-MS experiments, and by comparison with literature values. Compounds 1-7 are reported for the first time from Astragalus taxa. All of the compounds were tested for their cytotoxic activities against a number of cancer cell lines. Among them, only 6 exhibited significant activity against human colon carcinoma (HT-29) at 2.69 ?M concentration. 
 Keywords:  Astragalus lycius, Isoflavone, Lignan, Cytotoxic activity, Cancer, Chemotaxanomy.