The First Electroanalytical Study Of Umifenovir (Arbidol) Used As A Potential Antiviral Drug For The Treatment of SARS-CoV-2: A Voltammetric Quantification On The Boron-Doped Diamond Electrode By Using Anionic Surfactant Media

Özok H. İ., Kıran M., Yunusoğlu O., Yardım Y.

Journal of the Electrochemical Society, vol.170, no.1, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 170 Issue: 1
  • Publication Date: 2023
  • Doi Number: 10.1149/1945-7111/acafa7
  • Journal Name: Journal of the Electrochemical Society
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Analytical Abstracts, Applied Science & Technology Source, Chemical Abstracts Core, Chimica, Compendex, Computer & Applied Sciences, INSPEC
  • Van Yüzüncü Yıl University Affiliated: Yes


© 2023 The Electrochemical Society (“ECS”). Published on behalf of ECS by IOP Publishing LimitedIn this work, an electroanalytical procedure for sensing umifenovir (arbidol) by square wave adsorptive stripping voltammetry (SW-AdSV) was developed utilizing an anodically pretreated boron-doped diamond electrode. Measurements of umifenovir using cyclic voltammetry with phosphate buffer solution (PBS, 0.1 M, pH 2.5) revealed irreversible behaviour, adsorption-controlled as well as an ill-defined (+1.13 V, PA1) and a well-defined (+1.47 V, PA2) two oxidation peaks. Umifenovir oxidations depend critically on supporting electrolytes and pH. The second oxidation peak (PA2) current of the umifenovir was enhanced by adding sodium dodecyl sulfate (SDS, anionic surfactant) in the chosen supporting electrolyte. Umifenovir was quantified using its second oxidation peak (PA2) at about +1.39 V. Using the optimized condition, the oxidation peak current of PA2 showed a linear relationship for umifenovir determination in the concentration range from 0.005 to 1.0 μg ml−1 (9.73 × 10−9−1.95 × 10−6 M), with a detection limit of 0.0014 μg ml−1 (2.72 × 10−9 M) in PBS (PH 2.5) with SDS. Finally, the developed approach was successfully utilized to determine umifenovir in the pharmaceutical formulation and urine samples. To the best of our knowledge, this is the first electroanalytical approach for voltammetric sensing of umifenovir.