Akademik Veri Yönetim Sistemi
3rd INTERNATIONAL EGE CONGRESS ON SCIENTIFIC RESEARCH, İzmir, Türkiye, 20 - 22 Aralık 2024, ss.346-350
The anti-inflammatory and antiangiogenic properties of corticosteroids (glucocorticoids or
steroids) have made them an attractive treatment option. Dexamethasone, one of the synthetic
glucocorticoids, is used as an adjunct in the treatment of many diseases due to its good
inflammatory, antiexudative, immunosuppressive and antiemetic effects. Dexamethasone is
given as prophylaxis together with certain drugs to patients receiving highly emetogenic
chemotherapy such as carboplatin and is a widely used drug when necessary. In some types of
cancer, the patient may receive chemotherapy and radiotherapy simultaneously
(chemoradiotherapy). In addition, the patient receiving dexamethasone may undergo any
radiological examination. In such a case, dexamethasone interacts with radiation.
Pharmacological drugs can reduce radiation damage in the body when administered before or
after radiation exposure. The aim of the study was to investigate the interaction parameters of
dexamethasone with radiation. In the study; The mass attenuation coefficient (μρ) values were
calculated in the energy range of 1 keV-1 GeV using the WinXCom code. Then, the effective
atomic numbers (Zeff) and electron densities (Nel) were theoretically derived using the μρ
values. As a result, it was observed that the μρ values decreased with increasing energy, while
the Zeff and Nel values decreased sharply between 1 keV and 100 keV. These parameters
generally remained constant between 100 keV and 500 keV, while the values increased with
increasing energy. As a result, it was evaluated how the radiation shielding parameters of the
examined sample changed depending on the energy.
Key Words: Dexamethasone, effective atomic number, mass attenuation coefficients