Synthesis of Novel Tetra-Substituted Pyrazole Derivatives from 2,3-Furandione


Genç H. , Taşdemir V. , Tozlu İ. , Öğün E.

LETTERS IN ORGANIC CHEMISTRY, cilt.16, ss.891-897, 2019 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 16 Konu: 11
  • Basım Tarihi: 2019
  • Doi Numarası: 10.2174/1570178616666190314150302
  • Dergi Adı: LETTERS IN ORGANIC CHEMISTRY
  • Sayfa Sayıları: ss.891-897

Özet

Synthesis of pyrazole-3-carboxylic acid was progressed via two different protocols, one of which is solid state. Pyrazole-3-carboxylic acid was converted into different derivatives such as ester, urea, amide and nitrile. The amide compound was converted to nitrile using SOCl2 and DMF. Solid state heating of carboxylic acid gave decarboxylated product. Cyclization of tetra-substituted pyrazole with hydrazines resulted in pyrazolopyridazinones. The antimicrobial activities of the synthesized pyrazole derivatives against Bacillus cereus, Escherichia coli, Micrococcus luteus, Staphylococcus aureus, and Saccharomyces cerevisiae were evaluated. One of the pyrazole derivatives which possess nitro group showed antimicrobial activity in only B. cereus, a Gram-positive bacteria, with an MIC of 128 mu g/mL.