Nucleophilic cyclization of N-propargylated pyrazole-5-carboxylates: synthesis of pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives

Mengeş M. F., Uygun M.

Turkish Journal of Chemistry, cilt.50, sa.2, ss.199-206, 2026 (SCI-Expanded, Scopus, TRDizin) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 2
  • Basım Tarihi: 2026
  • Doi Numarası: 10.55730/1300-0527.3790
  • Dergi Adı: Turkish Journal of Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.199-206
  • Anahtar Kelimeler: fused heterocycles, hydrazine hydrate, Nucleophilic cyclization, pyrazolopyrazinones, pyrazolotriazepinones
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

Cyclization reactions are among the most important and widely used methods for synthesizing biologically active fused heterocyclic compounds. In the present study, pyrazolopyrazinone derivatives (10a–i) were synthesized from N-propargylated pyrazoles via nucleophilic cyclization with hydrazine hydrate under a nitrogen atmosphere. Nuclear magnetic resonance (NMR) spectral analyses confirmed that ring closure proceeded in a manner consistent with the formation of a six-membered pyrazinone moiety. In addition, the pyrazolotriazepinone derivative 15c was synthesized using an alternative approach. In this method, substitution with chloroacetone was first carried out, followed by ring closure with hydrazine hydrate, affording a seven-membered triazepinone system. Comparison of the NMR spectra of the resulting compounds clearly revealed structural differences between the two systems.