The strontium (Sr2+) and chlorine (Cl-) substituted tricalcium phosphate (TCP) were synthesized via aqueous precipitation method. To understand the effect of the Sr2+ and Cl- doping on mechanical properties of tricalcium phosphate (TCP) ceramics, dense TCP compacts of different compositions were prepared and sintered at 1100 degrees C for 1 h. X-ray diffraction of sintered samples revealed that dopants turn into beta-TCP to HA phase transformation during sintering. The binary combination and amount of co-dopants significantly affect the microstructure. The microhardness of the samples increased with increasing of the Sr2+ and Cl- ion concentrations. Cl- ion addition, 2.5-10 mol% affect micro hardness results negatively. A comparison between samples were carried out and differences were considered statistically significant at p < 0.05 (standard deviation: 1.2296 GPa). (C) 2019 Elsevier B.V. All rights reserved.