Investigation of the protective effect of thymoquinone of U87 cells induced by beta-amyloid


Ozbolat G., Alizade A.

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, vol.122, no.10, pp.748-752, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 122 Issue: 10
  • Publication Date: 2021
  • Doi Number: 10.4149/bll_2021_120
  • Journal Name: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Page Numbers: pp.748-752
  • Keywords: thymoquinone, amyloid-beta, U87, SOD, CAT, caspase-3, ALZHEIMERS-DISEASE, ACTIVATION, CASPASE-3, ANTIOXIDANT, DEMENTIA, BRAIN
  • Van Yüzüncü Yıl University Affiliated: No

Abstract

BACKGROUND: Thymoquinone (TQ) is the active compound extracted from Nigella sativa which has been reported to possess various pharmacological attributes. This study shows that Thymoquinone (TQ) is an Alzheimer's disease (AD) model cell line on amyloid-beta (A beta)-induced U87 (human astrocytoma cell line) in beta-amyloid (A beta)-induced in vitro Alzheimer's Disease (AD) model.