AIM: The aim of this case report is to evaluate the outcome of non-surgical root canal treatment of a lower central tooth with chronic apical periodontitis and extraoral sinus tract. CASE REPORT: A 24-year-old female patient came to our clinic with esthetic complaints due to missing tooth in lower anterior region. In the anamnesis taken from the patient, it was said that he had trauma to his lower anterior teeth 10 years ago and that his right lower central tooth was avulsed. In the clinical examination, there is no pain on percussion and a negative response in the electric pulp test were detected in the right lower lateral and left lower central teeth. In addition, extraoral sinus tract was observed at the tip of the chin (Figure 1). Radiological examination revealed a large radiolucent area in the periapical region of the left lower central tooth (Figure 1). Root canal treatments of the right lower lateral and left lower central teeth was initiated, and calcium hydroxide medicament was applied to the root canals. Root canals were closed temporarily and an appointment was scechuled two weeks later. After two weeks, it was observed that clinical symptoms decreased and the sinus tract at the tip of the chin started to heal. The temporary filling and calcium hydroxide were removed. In the final irrigation, the irrigation solutions were activated using the sonic activation system. Then, the root canal was filled with gutta-percha and resin root canal sealer using the lateral compaction technique (Figure 2). At 2, 6 and 12 months follow-up, it was determined that the teeth were asymptomatic, the extraoral sinus tract improved and the radiolucency in the apical region decreased (Figure 3,4,5). CONCLUSION: Extraoral sinus tracts of odontogenic origin can be successfully treated with non-surgical root canal therapy.