Protective effect of myricetin, apigenin, and hesperidin pretreatments on cyclophosphamide-induced immunosuppression


Berköz M. , YALIN S., ÖZKAN YILMAZ F., ÖZLÜER HUNT A., Krosniak M., Francik R., ...More

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, vol.43, no.3, pp.353-369, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.1080/08923973.2021.1916525
  • Title of Journal : IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
  • Page Numbers: pp.353-369

Abstract

Aim: Major side effects of cyclophosphamide administration are immunosuppression and myelosuppression. The immunomodulatory effects of plant bioactive compounds on chemotherapy drug-induced immunosuppression may have significant effects in cancer treatment. For this reason, we investigated the immunomodulatory effect of myricetin, apigenin, and hesperidin in cyclophosphamide-induced immunosuppression in rats.