Protective effect of myricetin, apigenin, and hesperidin pretreatments on cyclophosphamide-induced immunosuppression


Berköz M., YALIN S., ÖZKAN YILMAZ F., ÖZLÜER HUNT A., Krosniak M., Francik R., ...More

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, vol.43, no.3, pp.353-369, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.1080/08923973.2021.1916525
  • Journal Name: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.353-369
  • Keywords: Cyclophosphamide, immunomodulatory effect, myricetin, apigenin, hesperidin, OXIDATIVE STRESS, ANTIINFLAMMATORY ACTIVITY, INTERFERON-GAMMA, ETHANOL EXTRACT, IN-VITRO, POLYSACCHARIDE, PROLIFERATION, MECHANISMS, TOXICITY, DAMAGE
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

Aim: Major side effects of cyclophosphamide administration are immunosuppression and myelosuppression. The immunomodulatory effects of plant bioactive compounds on chemotherapy drug-induced immunosuppression may have significant effects in cancer treatment. For this reason, we investigated the immunomodulatory effect of myricetin, apigenin, and hesperidin in cyclophosphamide-induced immunosuppression in rats.