Protective effect of myricetin, apigenin, and hesperidin pretreatments on cyclophosphamide-induced immunosuppression
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, vol.43, no.3, pp.353-369, 2021 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 43 Issue: 3
- Publication Date: 2021
- Doi Number: 10.1080/08923973.2021.1916525
- Journal Name: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
- Page Numbers: pp.353-369
- Keywords: Cyclophosphamide, immunomodulatory effect, myricetin, apigenin, hesperidin, OXIDATIVE STRESS, ANTIINFLAMMATORY ACTIVITY, INTERFERON-GAMMA, ETHANOL EXTRACT, IN-VITRO, POLYSACCHARIDE, PROLIFERATION, MECHANISMS, TOXICITY, DAMAGE
- Van Yüzüncü Yıl University Affiliated: Yes
Abstract
Aim: Major side effects of cyclophosphamide administration are immunosuppression and myelosuppression. The immunomodulatory effects of plant bioactive compounds on chemotherapy drug-induced immunosuppression may have significant effects in cancer treatment. For this reason, we investigated the immunomodulatory effect of myricetin, apigenin, and hesperidin in cyclophosphamide-induced immunosuppression in rats.