Protective effect of myricetin, apigenin, and hesperidin pretreatments on cyclophosphamide-induced immunosuppression

Berköz, Mehmet; YALIN, SERAP; ÖZKAN YILMAZ, FERBAL; ÖZLÜER HUNT, ARZU; Krosniak, Miroslaw; Francik, Renata; Yunusoğlu, Oruç; Adiyaman, Abdullah; Gezici, Hava; Yigit, Ayhan; Unal, Seda; Volkan, Davut; Yildirim, Metin

doi:10.1080/08923973.2021.1916525

Protective effect of myricetin, apigenin, and hesperidin pretreatments on cyclophosphamide-induced immunosuppression

Berköz M., YALIN S., ÖZKAN YILMAZ F., ÖZLÜER HUNT A., Krosniak M., Francik R., ...Daha Fazla

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, cilt.43, sa.3, ss.353-369, 2021 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 43 Sayı: 3
Basım Tarihi: 2021
Doi Numarası: 10.1080/08923973.2021.1916525
Dergi Adı: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
Sayfa Sayıları: ss.353-369
Anahtar Kelimeler: Cyclophosphamide, immunomodulatory effect, myricetin, apigenin, hesperidin, OXIDATIVE STRESS, ANTIINFLAMMATORY ACTIVITY, INTERFERON-GAMMA, ETHANOL EXTRACT, IN-VITRO, POLYSACCHARIDE, PROLIFERATION, MECHANISMS, TOXICITY, DAMAGE
Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

Aim: Major side effects of cyclophosphamide administration are immunosuppression and myelosuppression. The immunomodulatory effects of plant bioactive compounds on chemotherapy drug-induced immunosuppression may have significant effects in cancer treatment. For this reason, we investigated the immunomodulatory effect of myricetin, apigenin, and hesperidin in cyclophosphamide-induced immunosuppression in rats.