Akademik Veri Yönetim Sistemi
Eastern Journal of Medicine, cilt.31, sa.2, ss.302-307, 2026 (Scopus, TRDizin)
This study aimed to evaluate the changes in oxidative stress markers in obese patients after bariatric surgery. The study included a total of 90 obese adults, divided into two groups: t hose who underwent bariatric surgery (case, n=45) and those who did not (control, n=45). Parameters such as 8-hydroxy-2-deoxyguanosine (8-OHdG; oxidative DNA damage), NADPH oxidase 2 (NOX2), NADPH oxidase 4 (NOX4), and thiol-disulfide homeostasis were compared in both groups. 73.3% of the participants were female; age distribution was similar between groups (p=0.698). Body mass index (BMI) was lower in the case group compared to the control group (31.5±7.2 vs. 38.2±3.7 kg/m²; p<0.001). Native thiol levels w ere lower in the case group (135.9±55.6 vs. 154.3±38.0 µmol/L; p=0.014) and 8-OHdG was higher (7.6±1.8 vs. 6.5±2.1 ng/mL; p=0.015); NOX2 and NOX4 levels were similar. In the case group, those with a BMI change ≥13 kg/m² had higher native thiol levels (p=0. 034) and lower 8-OHdG levels (p=0.045) than with a BMI change <13kg/m². A positive correlation was found between BMI change and native thiol levels (r=0.363; p=0.017). As the amount of weight loss increased, the disulfide/native thiol ratio decreased (r=−0.389; p=0.013) and the native/total thiol ratio increased (r=0.322; p=0.040). Although overall oxidative stress markers (high 8-OHdG, low native thiol) were observed in obese patients who underwent bariatric surgery, improvements in oxidative stress marker s were detected in those with greater BMI reduction. The findings suggest that effective weight loss after surgery may increase antioxidant capacity and reduce DNA oxidative damage. Long-term prospective studies are needed to clarify this relationship.