Evaluation of anti-cancer activity of Geraniin in laryngeal cancer Hep-2 cell line
Medicine Science, cilt.15, sa.2, ss.776-781, 2026 (TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 15 Sayı: 2
- Basım Tarihi: 2026
- Doi Numarası: 10.5455/medscience.2025.10.292
- Dergi Adı: Medicine Science
- Derginin Tarandığı İndeksler: TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.776-781
- Van Yüzüncü Yıl Üniversitesi Adresli: Evet
Özet
To investigate the anti-cancer activity, including anti-proliferative, anti-inflammatory, anti-metastatic, and apoptotic effects of Geraniin on the laryngeal cancer
human epidermoid carcinoma 2 Hep-2 cell line. The laryngeal cancer Hep-2 cell line was procured from an official institution under a research project. To assess
the anti-proliferative properties of Geraniin, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) was employed. Various concentrations of
Geraniin were administered to the Hep-2 cells for 24 hours, following which its anti-inflammatory, anti-metastatic, and pro-apoptotic effects were evaluated. As
a result, different concentrations of Geraniin showed different anti-proliferative roles in the laryngeal cancer Hep-2 cell line. However, the effects of Geraniin on
inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), transforming growth factor-beta (TGF-β), and
granulocyte-macrophage colony-stimulating factor (GM-CSF), angiogenesis/metastasis biomarker vascular endothelial growth factor (VEGF), and pro-apoptotic
indicators such as Caspase 3, 8 and 9 were not statistically different in half lethal concentration 50% (½LC50), LC50, and double LC50 (2LC50) concentrations than
that in LC0 concentration. Geraniin has an anti-proliferative role in the laryngeal cancer Hep-2 cell line. However, anti-inflammatory, anti-metastatic, and proapoptotic
effects of Geraniin were not statistically significant. This may be associated with the exposure duration of the cells to Geraniin. This is the first study on
this research area, and further studies are needed to evaluate this topic.
Keywords: Geraniin, larynx cancer, cell line, metastasis, cell proliferation