Gastric Intestinal Metaplasia and Covid 19 Infection

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Aydın M., Dülger A. C. , Özer S., Dirik Y., Keskin S., Demir C.

Eastern Journal of Medicine, vol.25, no.4, pp.571-575, 2020 (Scopus)

  • Publication Type: Article / Article
  • Volume: 25 Issue: 4
  • Publication Date: 2020
  • Doi Number: 10.5505/ejm.2020.68916
  • Journal Name: Eastern Journal of Medicine
  • Journal Indexes: Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.571-575
  • Van Yüzüncü Yıl University Affiliated: Yes


Gastric intestinal metaplasia (GIM) is defined as immigration of enteric or colonic mucosa within gastric lining.Gastric intestinal metaplasia (GIM) is a premalign condition seen in gastric lining. It is prevalent in Asia and may lead to gastric carcinoma at a rate of 1% annually. COVID 19, which has been a global issue since late 2019, causes mostly respiratory symptoms; however, some patients may present with gastrointestinal symptoms including diarrhea, vomiting (5%) and abdominal pain ( 3.8%).We tried in this text to handle any possible association between COVID 19 infection and GIM. In this retrospective study we included 39 COVID 19 patients and 180 age-matched control subjects to compare rate of intestinal metaplasia. All statistical analyses were performed with SAS software (SAS Institute, Cary, N.C.). The clinical and radiological characteristics of patients were compared using Student's t-test. Intestinal metaplasia was found in 11 (28%) of 39 patients while in 7 (3,9%) of 181 controls, which meant a statistical significance (p<0,05). Of the 181 subjects, atrophy was found in 39 (21%) whereas it was noted in 9 (23%) of 39 patients, which yielded no statistical significance (p>0,05). We found that GIM is a premalignant condition that can lead to COVID 19 infection.