beta-Escin reduces cancer progression in aggressive MDA-MB-231 cells by inhibiting glutamine metabolism through downregulation of c-myc oncogene

Akar S., ALTUNTAŞ H., HAMURCU Z.

MOLECULAR BIOLOGY REPORTS, vol.49, no.8, pp.7409-7415, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 8
  • Publication Date: 2022
  • Doi Number: 10.1007/s11033-022-07536-5
  • Journal Name: MOLECULAR BIOLOGY REPORTS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.7409-7415
  • Keywords: Apoptosis, ASCT2, Breast cancer, beta-Escin, Glutamine, GLS1, Migration, c-myc, MDA-MB-231, BREAST-CANCER, SUPPRESSES PROLIFERATION, IN-VITRO, KAPPA-B, APOPTOSIS, RESISTANCE, MIGRATION, INVASION, GEMCITABINE, EXPRESSION
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

Background The c-myc oncogene, which causes glutamine dependence in triple negative breast cancers (TNBC), is also the target of one of the signaling pathways affected by beta-Escin.