Electrochemical Biosensor Designing for Investigation of Ciprofloxacine
Pharmata, cilt.6, sa.2, ss.68-73, 2026 (TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 6 Sayı: 2
- Basım Tarihi: 2026
- Doi Numarası: 10.62425/pharmata.1787148
- Dergi Adı: Pharmata
- Derginin Tarandığı İndeksler: TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.68-73
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Van Yüzüncü Yıl Üniversitesi Adresli: Evet
Özet
Objective: Quinolone antibiotics deserve careful research due to their unique effects on bacteria and viruses. This will form the basis for synthesizing new generations of drugs that could prevent the impending human deaths caused by antibiotic resistance. For this purpose, in this study we designed a comparison method for the interaction mechanism of DNA and Ciprofloxacine (CIP). The effects of CIP on different DNA sequences were studied electrochemically. Methods: The electrochemical DNA-based biosensor was designed for interaction between fluoroquinolone antibiotic CIP and DNA (dsDNA and ssDNA) sequences by using a pencil graphite electrode (PGE) with the voltammetry technique. Consequently, the developed biosensor provides a suitable stage for the analysis of CIP-DNA interaction sensitively. Results: In the present study, the interaction of the antibacterial drug was investigated with the DNA-modified electrodes. The binding mechanism of the antibacterial drug CIP with dsDNA and ssDNA was determined by using the electrochemical method. For this purpose, DNA-modified electrodes were prepared and interacted with CIP, then measured by electrochemical analysis. Conclusion: In the present study, the binding effect of the antibacterial drug obtained from two different methods on DNA was examined together.