CYTOPROTECTIVE EFFECTS OF BORIC ACID AND COENZYME Q(10) THERAPY ON INDUCED PULMONARY FIBROSIS IN RESPONSE TO INTRATRACHEAL ADMINISTRATION OF BLEOMYCIN IN RATS

Oto G., Ekin S., Celikezen F. C., Yener Z., Tanrıtanır P., Ozdeinir H., ...Daha Fazla

FRESENIUS ENVIRONMENTAL BULLETIN, cilt.22, ss.2428-2434, 2013 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22
  • Basım Tarihi: 2013
  • Dergi Adı: FRESENIUS ENVIRONMENTAL BULLETIN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.2428-2434
  • Anahtar Kelimeler: Bleomycin, boric acid, coenzyme Q(10), pulmonary fibrosis, rat, INDUCED LUNG FIBROSIS, ALPHA-TOCOPHEROL, TRACE-ELEMENTS, DIETARY BORON, SUPEROXIDE, ERDOSTEINE, DEFICIENCY, TOXICITY, OXIDANT, SERUM
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

This study was designed to examine cytoprotective effects of boric acid and CoQ(10) on a model of bleomycin-induced lung fibrosis. A total of 32 female Wistar albino rats (200-250 g, n=8) were randomly divided into four groups (control, bleomycin, bleomycin + boric acid, and bleomycin + boric acid + CoQ(10)). Rats in the control group were given equal volumes of saline intratracheally. Lung fibrosis was induced by intratracheal administration of bleomycin hydrochloride (7.5 mg/kg in 0.9% NaCl) to rats under anaesthesia. In the treatment groups, the rats were treated with boric acid (10 mg/kg per day; perorally) and CoQ(10) (4 mg/kg per day; intraperitoneally) for 30 days. All animals were sacrificed at the end of the experiment. The lung, liver, kidney, and spleen tissues were excised, taken for histopathological evaluation, and stored for the measurement of SOD and GSH-Px activities with trace element and minerals. As a result, boric acid and boric acid + CoQ(10) had preventive roles on bleomycin-induced lung fibrosis in rats.