Synthesis, Characterization and DNA Interaction Activities of the Peripherally Tetra Diethyl (phenyl)malonate Substituted Zn(II) and Co(II) Phthalocyanine Complexes
Journal of the Chemical Society of Pakistan, cilt.48, sa.2, ss.156-166, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 48 Sayı: 2
- Basım Tarihi: 2026
- Dergi Adı: Journal of the Chemical Society of Pakistan
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core
- Sayfa Sayıları: ss.156-166
- Anahtar Kelimeler: Absorption spectroscopy, Cobalt (II), DNA interaction, Emission Spectroscopy, Phthalocyanines, Zinc (II)
- Van Yüzüncü Yıl Üniversitesi Adresli: Evet
Özet
The peripherally tetra-substituted zinc (II) and cobalt (II) phthalocyanine complexes containing diethyl 3,4-dicyanophenylmalonate were synthesized and characterized. These newly synthesized complexes have been described by utilizing FT-IR and UV/Vis procedures. Electronic absorption, fluorescence, melting denaturation, viscosity and electrophoresis procedures were applied to evaluate the interaction mechanism of tetra substituted 4 and 5 complexes with CT-DNA. Electronic spectra and emission experiments confirmed that 4 and 5 interact substantially by CT-DNA. The binding constant values for 4 and 5 were determined as 1.87 × 106 M-1 and 1.64 × 106 M-1, respectively. Kb data disclosed that the complexes attach to DNA through an intercalative binding mechanism. The results obtained from melting point technique also confirmed that the attachment of 4 and 5 complexes to DNA is an intercalative manner. In addition to above techniques, electrophoresis and viscosity technique were utilized to explain interaction features of 4 and 5 complexes with DNA. The findings obtained from viscosity and electrophoresis procedures demonstrated that the complexes interact with the DNA. All the data verified that 4 and 5 complexes may have a potential anticancer features.