Chiral Catalysts Utilized in the Nucleophilic Addition of Dialkyl-zinc Reagents to Carbonyl Compounds

Cetin A.

LETTERS IN ORGANIC CHEMISTRY, cilt.17, sa.8, ss.571-585, 2020 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 17 Sayı: 8
  • Basım Tarihi: 2020
  • Doi Numarası: 10.2174/1570178617666191220145038
  • Dergi Adı: LETTERS IN ORGANIC CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.571-585
  • Anahtar Kelimeler: Asymmetric synthesis, amino alcohol, binols, chirality, chiral recognition, Ee, ENANTIOSELECTIVE DIETHYLZINC ADDITION, ASYMMETRIC TRANSFER HYDROGENATION, ORGANOZINC ADDITIONS, PYRIDINE-DERIVATIVES, OXAZOLINE LIGANDS, BINOL LIGANDS, ALDEHYDES, ALKYLATION, ALCOHOLS, DISELENIDES
  • Van Yüzüncü Yıl Üniversitesi Adresli: Hayır

Özet

The aim of this review is an overview of diverse dialkyl zinc pro-chiral aldehydes addition reactions. One way of conducting asymmetric reactions is through the use of chiral catalyst. Therefore, new chiral ligands have attracted considerable attention in organic chemistry. Carbon-carbon bond formation reactions are an active research topic. The addition of dialkyl zinc to pro-chiral aldehydes is one of these popular reactions. Also, the chiral amino alcohols are important substrates for drug synthesis. These chiral ligands can be prepared by a simple synthetic way from easily accessible starting materials. This article reviews current catalyst reactions with the addition of dialkyl zinc to carbonyl compounds.