A novel class for carbonic anhydrases inhibitors and evaluation of their non-zinc binding


Kuzu B. , Tan Uygun M. , GÜLÇİN İ., Mengeş N.

ARCHIV DER PHARMAZIE, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume:
  • Publication Date: 2021
  • Doi Number: 10.1002/ardp.202100188
  • Title of Journal : ARCHIV DER PHARMAZIE

Abstract

In this study, 23 different imidazole derivatives were synthesized, and the inhibitory properties of these derivatives against carbonic anhydrase I and II isoenzymes were investigated for the first time. The inhibition concentrations of the imidazole derivatives were found to be in the range of 2.89-115.5 nM. Docking studies examined the binding properties of the imidazole derivatives, and the structure-activity relationship is discussed. Theoretical calculations showed that the binding mode of the imidazole ring was non-zinc binding.