Akademik Veri Yönetim Sistemi
Journal of the Science of Food and Agriculture, 2026 (SCI-Expanded, Scopus)
BACKGROUND: Hazelnuts and foods produced using hazelnuts are consumed with pleasure, but it is important to evaluate the waste generated during hazelnut processing and determine their usage methods. RESULTS: This study was conducted to determine the changes in bioactive components, bioaccessibility and antidiabetic activity of nanoparticles synthesized using soy lecithin from hazelnut wastes. The shell-derived nanoparticles had the highest zeta potential (−38.62 mV), and the smallest particle size and polydispersity index values. The production efficiency of nanoparticles was in the range of 79.10–89.46%, and the loading capacity was in the range of 38.17–52.59%. The antioxidant properties and thermal stability of the shell nanoparticle were higher. The highest gallic acid, rutin, o-coumaric acid, quercetin and kaempferol were measured in shell nanoparticles. In the bioaccessibility results, gallic acid (69.47%), protocatechuic acid (61.28%), quercetin (61.50%) and kaempferol (52.07%) were at the highest values in the shell nanoparticle. Lipid peroxidation inhibition was highest in shell nanoparticles (8.41 mg mL−1), while the lowest effect was measured in husk nanoparticles. The order of antidiabetic activity was shell nanoparticles > skin nanoparticles > husk nanoparticles. The investigation revealed that the nanoparticles exhibited significant anticancer activity in the MCF-7 breast cancer and HT-29 colon cancer cell lines. Principal component analysis showed that antioxidant properties are the key drivers of principal component one (PC1), while enzyme activities influence principal component two (PC2). CONCLUSION: The results obtained revealed the potential use of nanoparticles produced from hazelnut waste (especially shell) for therapeutic purposes and prevention of diseases associated with oxidative stress. © 2026 The Author(s). Journal of the Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.