Akademik Veri Yönetim Sistemi
Gynecological Endocrinology, cilt.27, sa.4, ss.241-247, 2011 (SCI-Expanded)
Objective. There is limited study about anti-inflammatory effect mechanism of tamoxifen. We aimed to investigate the anti-inflammatory activity of tamoxifen to see whether adrenal gland hormones have roles in the anti-inflammatory effect mechanism of tamoxifen and to evaluate the relationship between anti-inflammatory activity and cyclooxygenase (COX) level. Study Design. Effects of tamoxifen, indomethacin and prednisolon on carrageenan-induced inflammatory paw oedema were investigated in intact and adrenalectomised rats. Also blood adrenalin and corticosterone levels and paw tissue COX levels determined biochemically. Results. Tamoxifen (5, 10 and 20mg/kg), indomethacin (5, 10 and 20mg/kg) and prednisolon (5mg/kg) produced anti-inflammatory effects in intact rats, however, they could not in adrenalectomized rats. 20mg/kg tamoxifen produced low anti-inflammatory effect. Tamoxifen and indomethacin decreased COX-2 levels in intact rats, but not in adrenalectomised rats. Tamoxifen produced anti-inflammatory effects by decreasing adrenalin levels, as indomethacin does. 20mg/kg tamoxifen decreased corticosterone levels. Conclusions. Tamoxifen was seen to suppress carrageenan-induced inflammation significantly. The dose of tamoxifen that decreases adrenalin levels maximally and decreases corticosterone levels minimally was found to produce the most potent anti-inflammatory effect. The reason why indomethacin is more potent in high doses may be that it decreases adrenalin levels strongly at these doses, without decreasing corticosterone levels. © 2011 Informa UK, Ltd.