Akademik Veri Yönetim Sistemi
Phosphorus, Sulfur and Silicon and the Related Elements, 2026 (SCI-Expanded, Scopus)
Bis-(4-benzylphenoxy) silicon phthalocyanine compound (3) was synthesized and characterized by UV–Vis, FT-IR, and 1H NMR spectroscopy. Subsequently, its antioxidant, antidiabetic, genotoxic, antimicrobial, antibiofilm, microbial cell viability, and photodynamic effects were evaluated. The antioxidant activity of 3 was determined using the DPPH method and was 35.35% at 100 mg/L. Within the scope of antidiabetic activity, α-amylase inhibition reached 37.49% at 100 mg/L, indicating that 3 possesses a considerable antidiabetic potential. Compound 3 caused complete DNA fragmentation at all tested concentrations, demonstrating a strong genotoxic effect. Antimicrobial activity was assessed by determining minimum inhibitory concentrations (MICs) against various microorganisms. Compound 3 exhibited the highest antimicrobial activity against Pseudomonas aeruginosa and Legionella pneumophila subsp. pneumophila, with MIC values of 32 mg/L. The antibiofilm activity of 3 increased with concentration against P. aeruginosa and Staphylococcus aureus, achieving inhibition rates of 89.95% and 75.81%, respectively, at 200 mg/L. In addition, 3 significantly reduced Escherichia coli cell viability, reaching an inhibition rate of 92.76% at 200 mg/L and exerting a strong suppressive effect on bacterial growth. Notably, under photodynamic conditions, 3 completely inhibited E. coli cell viability (100% inhibition) at all tested concentrations (50–200 mg/L), indicating an exceptionally strong photodynamic antimicrobial effect.