Simple, rapid, and sensitive electrochemical determination of antithyroid drug methimazole using a boron-doped diamond electrode


SEYIDAHMET S., Dönmez F., Yardım Y., Senturk Z.

JOURNAL OF THE IRANIAN CHEMICAL SOCIETY, vol.16, no.5, pp.913-920, 2019 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 5
  • Publication Date: 2019
  • Doi Number: 10.1007/s13738-018-1562-1
  • Journal Name: JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.913-920
  • Keywords: Methimazole, Anodically pretreated boron-doped diamond electrode, Square wave voltammetry, Pharmaceutical samples, ADSORPTIVE STRIPPING VOLTAMMETRY, ENHANCED RAMAN-SCATTERING, SPECTROPHOTOMETRIC DETERMINATION, ANIONIC SURFACTANT, GAS-CHROMATOGRAPHY, CARBON, URINE, PERFORMANCE, SAMPLES, NANOCOMPOSITE
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

This paper aims a rapid, cheap, simple and modification-free electroanalytical methodology using a boron-doped diamond electrode pretreated anodically for the determination of antithyroid drug methimazole in pharmaceutical samples. The drug was irreversibly oxidized which was a diffusion-controlled process. Using square wave voltammetry, a linear response was obtained for methimazole determination in Britton-Robinson buffer (pH 5.0) at +0.89V (vs. Ag/AgCl). Linearity was found between the oxidation peak currents and the concentration of methimazole from 0.5 to 25.0 mu g mL(-1) (4.38x10(-6)-2.19x10(-4)M) with a detection limit of 0.085 mu g mL(-1) (7.45x10(-7) M). The proposed method was applied for the determination of methimazole in commercial tablet samples.