Cytotoxic effects of 4-octylphenol on fish hepatocytes

Kaptaner B.

CYTOTECHNOLOGY, cilt.68, sa.4, ss.1577-1583, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 68 Sayı: 4
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s10616-015-9916-3
  • Dergi Adı: CYTOTECHNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1577-1583
  • Anahtar Kelimeler: 4-Octylphenol, Cytotoxicity, Antioxidant defenses, Isolated fish hepatocytes, Alburnus tarichi, OXIDATIVE STRESS, BISPHENOL-A, CHALCALBURNUS-TARICHI, AQUATIC ENVIRONMENT, CARASSIUS-AURATUS, MALE RATS, NONYLPHENOL, OCTYLPHENOL, EXPOSURE, LIVER
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

The present study was conducted to determine cytotoxic effects of 4-octylphenol (4-OP) on primary cultured hepatocytes of pearl mullet (Alburnus tarichi). Lactate dehydrogenase (LDH) release, malondialdehyde (MDA) level, antioxidant enzymes [superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione-S-transferase (GST)] and glutathione (GSH) content were measured after 24-h exposure to 4-OP. 4-OP caused dose- and time-dependent increases in LDH release. Significant induction of MDA level and decrease in GSH content were found. SOD and GPx activities were decreased while GST activity was increased. These findings suggest that 4-OP leads to cytotoxicity by depressing antioxidant defenses in fish hepatocytes.