Essential Oil Contents of Hypericum linarioides, H. helianthemoides, and H. lydium with Their Biological Activities: Importance of Hypericum Genus in the Cosmeceutical and Pharmaceutical Industries

Akdeniz M., Yener I., Ertaş A., Dincel D., Fırat M., Özhan Kocakaya Ş., ...More

PHARMACEUTICAL CHEMISTRY JOURNAL, vol.1, no.1, pp.1, 2024 (SCI-Expanded)

  • Publication Type: Article / Article
  • Volume: 1 Issue: 1
  • Publication Date: 2024
  • Doi Number: 10.1007/s11094-023-03011-y
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core
  • Page Numbers: pp.1
  • Van Yüzüncü Yıl University Affiliated: Yes


In the literature, more than 3000 studies have been carried out on species in the Hypericum genus in the last

ten years, especially for H. perforatum. The importance of Hypericum species in traditional medicine and

modern medicine is increasing day by day. From this point of view, the chemical composition of H. linarioides,

H. helianthemoides, and H. lydium essential oils was analyzed by GC-MS/FID. In addition, their antioxidant,

cytotoxic and antimicrobial activities along with their enzyme inhibitory potentials (cholinesterase,

urease, tyrosinase, elastase and, collagenase) were defined. Also, in vitro and in silico studies of the major

components of the species have been carried out on the studied enzymes. H. linarioides and H. helianthemoides

were found to be rich in monoterpene hydrocarbons (63.96% and 43.86%, respectively), and H. lydium

in sesquiterpene hydrocarbons (48.41%). The major components were indicated as -pinene for H. linarioides

(50.39%) and for H. helianthemoides (36.84%), and -selinene for H. lydium (10.12%). H. lydium essential

oil exhibited very high cytotoxic activity on breast cancer (MCF-7) (selectivity indices SI: 12) and colon

cancer (HT-29) (SI: 2) cell lines. In particular, the selectivity indice value in MCF-7 cell lines of H. lydium

could have natural therapeutic potential for breast cancer. H. lydium possessed neuropharmacological potential

due to its high anticholinesterase activity. Since H. linarioides indicated high anti-aging potential

(tyrosinase, elastase, and collagenase enzyme inhibitory activities), it could be used in the cosmetic industry.