The effects of dexmedetomidine on liver injury in rats with experimental sepsis: A histopathological and immunohistochemical study Deneysel sepsis oluşturulan sıçanlarda deksmedetomidinin karaciğer hasarı üzerine etkileri: Histopatolojik ve immünohistokimyasal bir çalışma
Ulusal Travma ve Acil Cerrahi Dergisi, cilt.31, sa.2, ss.112-118, 2025 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 31 Sayı: 2
- Basım Tarihi: 2025
- Doi Numarası: 10.14744/tjtes.2025.55338
- Dergi Adı: Ulusal Travma ve Acil Cerrahi Dergisi
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, MEDLINE, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.112-118
- Anahtar Kelimeler: Dexmedetomidine, E. coli, histopathology, liver, rat, sepsis
- Van Yüzüncü Yıl Üniversitesi Adresli: Evet
Özet
BACKGROUND: In the rat sepsis model, the protective effect of dexmedetomidine (Dex) in sepsis-induced tissue injuries by reduc-ing inflammation is still unclear. Research is ongoing to determine whether Dex modulates sepsis-induced tissue injury. The aim of this experimental study was to investigate the effect of Dex on liver injury in sepsis rats histopathologically and immunohistochemically. METHODS: In this study, sepsis was induced in rats by a 10 ml/kg E. coli injection, and the protective efficacy of Dex against liver damage was investigated through histopathological and immunohistochemical findings by the intraperitoneal administration of 100 μg/ kg Dex. RESULTS: In our results, the most striking and basic morphological changes in the liver tissues of sepsis group rats were neutrophil leukocyte infiltrations in and around the vessels. In Dex-treated groups, neutrophil leukocyte infiltrations were more prominent, and marked dilatations were observed in the vessels. The fact that inflammatory reactions were more prominent in the Dex-treated groups was thought to be related to the increase in vascular permeability due to Dex's vasodilation effect. CONCLUSION: According to the histopathological and immunohistochemical findings obtained in the present study, we conclude that Dex did not alleviate sepsis-induced liver inflammation in a rat sepsis model.