Reprogramming Interorgan Communication: The Liver–Brain Immunometabolic Axis as a Metabolite-Centered Paradigm
1st Neuro-Cell Molecular Research Congress (NCMR2026), Kastamonu, Türkiye, 26 - 29 Ağustos 2026, cilt.1, ss.1, (Özet Bildiri)
- Yayın Türü: Bildiri / Özet Bildiri
- Cilt numarası: 1
- Basıldığı Şehir: Kastamonu
- Basıldığı Ülke: Türkiye
- Sayfa Sayıları: ss.1
- Van Yüzüncü Yıl Üniversitesi Adresli: Evet
Özet
The liver–brain axis extends beyond classical endocrine, neural, and inflammatory pathways. We propose an immunometabolic framework in which the liver integrates nutritional, microbial, and environmental cues and generates bioactive metabolites that function as systemic signals. Bile acids, short-chain fatty acids, tryptophan derivatives, ketone bodies, and microbiota-associated metabolites may influence immune-cell metabolism, microglial function, blood–brain barrier integrity, and neuronal bioenergetics. Our four-stage model comprises hepatic metabolic sensing, metabolite encoding, systemic immune decoding, and neurofunctional adaptation. This metabolite-centered perspective provides an integrative framework for understanding interorgan communication and may reveal novel biomarkers and therapeutic targets in translational neuroscience.