Content analysis, nanoparticle forming potential and acaricidal effects on Tick (Hyalomma marginatum) of essential oils from two common Thymbra species


Çavuş Kaya E., Akdeniz M., Uğurlu P., Yener I., Fırat M.

JOURNAL OF ESSENTIAL OIL-BEARING PLANTS, vol.27, no.1, pp.1-20, 2024 (SCI-Expanded)

  • Publication Type: Article / Article
  • Volume: 27 Issue: 1
  • Publication Date: 2024
  • Doi Number: 10.1080/0972060x.2024.2307907
  • Journal Name: JOURNAL OF ESSENTIAL OIL-BEARING PLANTS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Analytical Abstracts, CAB Abstracts, Veterinary Science Database
  • Page Numbers: pp.1-20
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

In this study, the fatty acid, essential oil and aroma composition of Thymbra

sintenisii Bornm. & Aznav. subsp. sintenisii Bornm. & Aznav (TSS) and

Thymbra sintenisii Bornm. & Azn. subsp. isaurica P.H.Davis (TSI) were

determined by GC-MS. The cytotoxic activity was determined with MTT

assay and antioxidant activities were determined with DPPH, ABTS,

CUPRAC methods. Urease, acetyl, butyryl, angiotensin, α-amylase,

tyrosinase, elastase, and collagenase enzyme inhibition activities of these

species were also determined. The acaricidal effects of essential oils from

aerial parts of TSS and TSI on ticks and the nanoparticle formation potential

of their essential oils with AgNO3 were determined and compared. The main

components of TSS essential oil and aroma were determined as carvacrol

and o-cemen (66.78 and 35.44%, respectively), the major components of

TSI essential oil and aroma were carvacrol and γ-terpinene (63.78 and

31.44%, respectively). The species exhibited remarkably high antioxidant

activity, particularly in the ABTS and CUPRAC methods. It was also

determined that the butyrylcholinesterase and acetylcholinesterase enzyme

inhibition activities (Inhibition%: 76.12±0.83 and 74.13±0.33, respectively)

of the species were quite high. Moderate antimicrobial activity against the

bacteria was observed for both essential oils, with MIC values ranging from

312 to 1250 μg/mL. Moreover, essential oils of these species showed good

acaricidal activity on Hyalomma marginatum (LC50: 11.82 μg/mL for TSS;

LC50: 57.64 μg/mL for TSI). The high antioxidant, anticholinesterase, and

acaracidal activities observed in both species are attributed to the presence

of carvacrol in their essential oils. The species have potential to be used in

food supplements-preservatives, pharmaceutical industry.