Akademik Veri Yönetim Sistemi
JOURNAL OF ESSENTIAL OIL-BEARING PLANTS, cilt.27, sa.1, ss.1-20, 2024 (SCI-Expanded)
In this study, the fatty acid, essential oil and aroma composition of Thymbra
sintenisii Bornm. & Aznav. subsp. sintenisii Bornm. & Aznav (TSS) and
Thymbra sintenisii Bornm. & Azn. subsp. isaurica P.H.Davis (TSI) were
determined by GC-MS. The cytotoxic activity was determined with MTT
assay and antioxidant activities were determined with DPPH, ABTS,
CUPRAC methods. Urease, acetyl, butyryl, angiotensin, α-amylase,
tyrosinase, elastase, and collagenase enzyme inhibition activities of these
species were also determined. The acaricidal effects of essential oils from
aerial parts of TSS and TSI on ticks and the nanoparticle formation potential
of their essential oils with AgNO3 were determined and compared. The main
components of TSS essential oil and aroma were determined as carvacrol
and o-cemen (66.78 and 35.44%, respectively), the major components of
TSI essential oil and aroma were carvacrol and γ-terpinene (63.78 and
31.44%, respectively). The species exhibited remarkably high antioxidant
activity, particularly in the ABTS and CUPRAC methods. It was also
determined that the butyrylcholinesterase and acetylcholinesterase enzyme
inhibition activities (Inhibition%: 76.12±0.83 and 74.13±0.33, respectively)
of the species were quite high. Moderate antimicrobial activity against the
bacteria was observed for both essential oils, with MIC values ranging from
312 to 1250 μg/mL. Moreover, essential oils of these species showed good
acaricidal activity on Hyalomma marginatum (LC50: 11.82 μg/mL for TSS;
LC50: 57.64 μg/mL for TSI). The high antioxidant, anticholinesterase, and
acaracidal activities observed in both species are attributed to the presence
of carvacrol in their essential oils. The species have potential to be used in
food supplements-preservatives, pharmaceutical industry.