Spray cooling process has many parameters such as extended surface, angle of inclination, effect of gravity, diameter of nozzle, angle of spray, mass flux, geometry of cooled surface, thermal performance and critical heat flux of spray etc. Many effective parameters to carry out the experiments with conventional test methods are both expensive and time consuming. As a solution in these circumstances, Taguchi method, which is one of the modern experimental design and optimization methods and very effective in solving such problems, was used in this study. Taguchi method, as well as being in effective to improve the quality of products, also gives the opportunity to achieve better results with much less experiment. Using Taguchi method, as well as to reach the target value exactly, the sensitivity of the design against uncontrollable factors is reduced to a minimum. Thus, the optimum tolerance range in cost and quality factors is determined. When compared to conventional experimental design methods, Taguchi method has many advantages.