Determination of the enol form of asymmetric 1,3-dicarbonyl compounds: 2D HMBC NMR data and DFT calculations

Tan M., Bildirici İ., Mengeş N.

JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, vol.83, no.9, pp.953-968, 2018 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 83 Issue: 9
  • Publication Date: 2018
  • Doi Number: 10.2298/jsc010318053t
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.953-968
  • Van Yüzüncü Yıl University Affiliated: Yes


In this study, a series of asymmetric aryl 1,3-dicarbonyl compounds were synthesized and their enol forms were observed via experimental data and theoretical calculations. According to the H-1- and C-13-NMR results, all the investigated compounds were found as a single enol form in CDCl3 solution. Moreover, their HMBC spectra were applied to identify the observed enol forms and correlations between certain protons and carbon atoms were considered. The dihedral angles of the asymmetric compounds that have aryl units on both sides were calculated by DFT to understand the reason for the observed enol forms. Small dihedral angles caused longer conjugation, resulting in more stable compounds and it was found that the observed enol forms were based on small dihedral angles, namely, resonance is the driving force. Furthermore, the compounds possessing both aryl and alkyl moieties prefer the enol form towards the aromatic ring side due to longer conjugation.