Glutathione S-transferase enzyme activity and protein expression in patients with recurrent tonsillitis and idiopathic tonsillar hypertrophy


Aydin S., Demir M. G. , OĞUZTÜZÜN S., KILIÇ M., Yılmaz C. , Dirican O.

BIOMEDICAL PAPERS-OLOMOUC, cilt.163, ss.349-354, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 163 Konu: 4
  • Basım Tarihi: 2019
  • Doi Numarası: 10.5507/bp.2019.002
  • Dergi Adı: BIOMEDICAL PAPERS-OLOMOUC
  • Sayfa Sayıları: ss.349-354

Özet

Objectives. The palatine tonsil is a significant part of the secondary immune system. Tonsillitis and idiopathic tonsillar hypertrophy (ITH) are the most common pathologies of this component. Although there are studies on their pathogenesis, there is insufficient study of the role of antioxidant agents. Glutathione S-transferase (GST) isozymes contribute to the antioxidation reactions in the tissue via the glutathione pathway. The purpose in this study was to reveal the levels of the GST enzyme activity and protein expression of GSTP1 and GSTA1 isozymes in patients with tonsillitis and tonsil hypertrophy, and to investigate their role in the pathogenesis of these diseases.