INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH, vol.34, no.4, pp.1944-1960, 2024 (SCI-Expanded)
The
medicinal plant Satureja cuneifolia
Ten. was widely utilized as spice, tea and traditional medicine. The objective
of the current study was to examine the chemical composition and in vitro biological activities (LOX,
MMP-1, and MMP-12 enzyme inhibition activity and cytotoxicity on A549 cell line)
of Satureja cuneifolia extracts and
essential oils. The essential oils of the flowering aerial parts were
hydro-distilled at four different distillation times (5, 30, 60, and 180 min)
using the Clevenger apparatus. The total essential oil and four fragments were
compared in terms of the major component, yield, and distillation time.
Volatile compounds of the infusion were extracted by using HS-SPME. Ethanolic
extract had the strongest inhibition activity on the LOX enzyme (84.50%), while
the essential oils exhibited more cytotoxic activity on the A549 cell line than
the extracts. The oils and the infusion were analyzed by GC-MS and the primary
chemicals identified by LC-MS/MS.