In present, new artemisinin-based organic compounds (1-6) are designed and synthesized in excellent yields (up to 97 %) via Steglich Esterification reactions. All new artemisinin derivatives are tested as anode catalysts for hydrazine electrooxidation reactions with electrochemical methods in 1 M KOH/0.5 M N2H4 solution. Hybrid molecule 1 exhibits the best catalytic activity in hydrazine electrooxidation reaction with 2.28 mA cm(-2) value. Moreover, response surface methodology (RSM) is applied to investigate of optimum electrode conditions. By using optimum conditions, hydrazine electrooxidation is obtained as 3.55324 mA cm(-2). As a result, artemisinin-based hybrid compounds may be alternative, and next-generation anode catalyst for direct hydrazine fuel cells.