Aminoalkylated Phenolic Chalcones: Investigation of Biological Effects on Acetylcholinesterase and Carbonic Anhydrase I and II as Potential Lead Enzyme Inhibitors

Yamali C., GÜL H. İ., Çakır T., Demir Y., GÜLÇİN İ.

LETTERS IN DRUG DESIGN & DISCOVERY, vol.17, no.10, pp.1283-1292, 2020 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 10
  • Publication Date: 2020
  • Doi Number: 10.2174/1570180817999200520123510
  • Journal Name: LETTERS IN DRUG DESIGN & DISCOVERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, Biotechnology Research Abstracts, EMBASE
  • Page Numbers: pp.1283-1292
  • Keywords: Mannich, chalcone, carbonic anhydrases, acetylcholinesterase, phenol, hCA I, hCA II, MANNICH BASE DERIVATIVES, MULTIFUNCTIONAL AGENTS, HCA IX, BIOACTIVITIES, CYTOTOXICITY, APOPTOSIS, DESIGN
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

Background: Phenolic Mannich bases have been reported as acetylcholinesterase (AChE) inhibitors for the medication of Alzheimer's disease. Carbonic Anhydrases (CAs) are molecular targets for anticonvulsant, diuretic and antiglaucoma drugs in the clinic. Phenolic compounds have also been mentioned as CA inhibitors. The importance of Mannich bases in drug design inspired our research group to design novel phenolic Mannic bases as potent enzyme inhibitors.