Histopathological and Oxidative Stress Effects of Bisphenol S in the Adrenal Glands of Male Rats
Biology Bulletin, cilt.53, sa.2, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 53 Sayı: 2
- Basım Tarihi: 2026
- Doi Numarası: 10.1134/s1062359025614284
- Dergi Adı: Biology Bulletin
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Artic & Antarctic Regions, BIOSIS, Zoological Record, Academic Search Ultimate (EBSCO), Natural Science Collection (ProQuest), Biological Science Database (ProQuest), Biomedical Reference Collection: Corporate Edition (EBSCO)
- Anahtar Kelimeler: adrenal gland, bisphenol S, GST activity, histopathology, oxidative stress, rats
- Van Yüzüncü Yıl Üniversitesi Adresli: Evet
Özet
Abstract: The current study aimed to examine the toxic effects of bisphenol S (BPS), which is preferred as an alternative instead of bisphenol A, on male Wistar albino rat adrenal glands. For this purpose, 28 adult rats were divided randomly into 4 different groups, each comprising 7. The normal control group was given drinking water each day by oral gavage. The vehicle control group was orally administrated a vehicle in which the test chemical was dissolved. The BPF-5 and BPF-20 groups were administrated BPS orally at concentrations of 5 and 20 mg/kg of body weight (bw) per day, respectively. All of the treatments were terminated after 28 days. Following this, the adrenal glands were removed and histopathological examinations and analyses of some antioxidant defense system indicators (malondialdehyde (MDA) level, glutathione S-transferase (GST) activity, and reduced glutathione (GSH) content) were performed. The BPS caused increased vacuolization and vacuolar degeneration in the cells of the zona fasciculata layer in the adrenal cortex. The BPS led to significant increases in the MDA level of the adrenal gland and decreased the GST activity at the highest dose. However, the GSH levels of the adrenal glands did not show significant changes after exposure to BPS. The data obtained showed that BPS could cause structural changes and induce oxidative stress in the adrenal gland. The utilization of the BPS in consumer products should be avoided considering the negative effects that it has on the adrenal gland and the possible health problems associated with those impacts.