FRESENIUS ENVIRONMENTAL BULLETIN, vol.20, no.7, pp.1661-1666, 2011 (SCI-Expanded)
In this study, the antagonistic effects of methanol extracts of Rhizoplaca chrysoleuca (RME) and Lecanora muralis (LME) were studied against effects of aflatoxin B-1 (AFB(1))-induced oxidative stress and genotoxicity in human lymphocytes in vitro. Results showed that 5 and 10 mu M concentrations of aflatoxin B-1 increased the frequencies of sister chromatid exchange (SCE), micronuclei (MN) and malondialdehyde (MDA) level, whereas superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities decreased. However, when 5 and 10 mu g/ml concentrations of LME and RME were added to AFB(1), the frequencies of SCE, MN and MDA level decreased but SOD and GPx activities increased. The results of this experiment have clearly shown that LME and RME have strong antioxidative and antigenotoxic effects, and may play a role in the anti-genotoxic activity mechanisms.