Akademik Veri Yönetim Sistemi
European Journal of Ophthalmology, cilt.19, sa.1, ss.80-85, 2009 (SCI-Expanded)
Purpose. This study examines the levels of oxidative damage in patients with retinopathy of prematurity (ROP). Methods. Fifty patients were recruited with a birthweight below 1500 g or gestational age below 32 weeks. The cases were classified into those who developed ROP (n=25) and those without ROP (n=25). The authors obtained blood and urine samples from each infant, for measuring 8-hydroxy 2-deoxyguanosine (8-OHdG) and malondialdehyde (MDA) levels, at the time of the first examination at 4-6 postnatal weeks. Results. A significant difference was observed in leukocyte and urine 8-OHdG levels in patients with ROP compared to those without ROP (p<0.001 for both). Similarly, a significant difference was observed in plasma and urine MDA levels in patients with ROP compared to those without ROP (p<0.001 for both). In addition, significant correlations were found between levels of 8-OHdG in leukocyte DNA and plasma MDA (r=0.859, p<0.001), and between levels of urine 8-OHdG excretion and urine MDA (r=0.563, p<0.001). Conclusions. 8-OHdG in leukocyte DNA and urine levels in premature infants can be useful as an indicator for ROP screening. © Wichtig Editore, 2009.