Effects of Clitoria Ternatea on renal ischemia and reperfusion injury in rats Efectos de la Clitoria Ternatea en la lesó renal por isquemia y repefusión en ratas

Melek Ş., UYAR A., Akkoyun H. T., ALTUN S., Akkoyun M. B., KARAGÖZOĞLU F., ...Daha Fazla

Revista Cientifica de la Facultad de Veterinaria, cilt.35, sa.2, ss.1-8, 2025 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 2
  • Basım Tarihi: 2025
  • Doi Numarası: 10.52973/rcfcv-e35657
  • Dergi Adı: Revista Cientifica de la Facultad de Veterinaria
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, Food Science & Technology Abstracts, Veterinary Science Database
  • Sayfa Sayıları: ss.1-8
  • Anahtar Kelimeler: clitoria ternatea, Clitoria ternatea, ischemia-reperfusion, isquemia-reperfusión, rat, rata, Riñóln, terapeutico, therpeutic
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

Ischemia-reperfusion (I/R) injury refers to damage caused by the temporary interruption of blood flow into an organ/ tissue and the restoration of circulation. This injury, which affects many vital organs, is still an important clinical and surgical problem. This study aims to investigate the effect of antioxidant and anti-inflammatory effects of Clitoria ternatea on renal I/R injury in rats. Twenty-four male Wistar albino rats were clustered into 4 groups, 6 rats in each (Control, I/R group, Clitoria ternatea group, I/R group + Clitoria ternatea group). At the end of the experimental procedures, all groups were euthanised in accordance with ethical rules. Blood and tissue samples were taken and subsequent biochemical (MDA, SOD, CAT, GSH-Px, BUN, Na, K, creatine), histopathological and immunohistochemical analyses demonstrated that Clitoria ternatea effectively prevented I/R-induced renal injury in rats. Based on these findings, Clitoria ternatea may be considered a potential therapeutic agent for the prevenstion of I/R-induced kidney damage.