VOLTAMMETRIC QUANTIFICATION OF A NONSTEROIDAL ANTI-INFLAMMATORY AGENT DIFLUNISAL BASED ON THE ENHANCEMENT EFFECT OF CATIONIC SURFACTANT ON BORON-DOPED DIAMOND ELECTRODE


KESKİN E., Allahverdiyeva S., Alali A., Yardım Y.

MACEDONIAN JOURNAL OF CHEMISTRY AND CHEMICAL ENGINEERING, vol.40, no.1, pp.11-20, 2021 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 1
  • Publication Date: 2021
  • Doi Number: 10.20450/mjcce.2021.2172
  • Title of Journal : MACEDONIAN JOURNAL OF CHEMISTRY AND CHEMICAL ENGINEERING
  • Page Numbers: pp.11-20
  • Keywords: diflunisal, boron-doped diamond electrode, voltammetry, cationic surfactant, pharmaceutical formulation, SQUARE-WAVE VOLTAMMETRY, CAPILLARY-ELECTROPHORESIS, SALICYLIC-ACID, DRUGS, NAPROXEN, TERBIUM, SENSORS, URINE, SERUM

Abstract

The present work describes a simple, fast and inexpensive voltammetric method for diflunisal measurement using a non-modified boron-doped diamond (BDD) electrode. The oxidation of the agent was irreversible and was a diffusion-controlled process. The sensitivity of the square wave voltammetric measurements were significantly improved when the cationic surfactant, cetyltrimethylammonium bromide (CTAB), was present in the supporting electrolyte solution. Using the square-wave mode, a linear response was obtained for diflunisal quantification in a 0.1 mol l(-1) phosphate buffer solution (pH 2.5) containing 5.10(-5) mol l(-1) CTAB at +1.07 V (vs. Ag/AgCl) (after 30 s accumulation under open-circuit conditions). Linearity was found for 0.05 to 2.0 mu g ml(-1) (2.0.10(-7) - 8.0.10(-6) mol l(-1)) with a detection limit of 0.013 mu g ml(-1) (5.2.10(-8) mol l(-1)). The developed approach could be used for the quantification of diflunisal in pharmaceutical formulations.