The Natural Diatomite from Caldiran-Van (Turkey): Electroanalytical Application to Antimigraine Compound Naratriptan at Modified Carbon Paste Electrode

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Caliskan N., Sogut E., Saka C., Yardım Y., Şentürk Z.

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, vol.13, no.8, pp.703-711, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 8
  • Publication Date: 2010
  • Doi Number: 10.2174/138620710791920356
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.703-711
  • Keywords: Diatomite, characterization, modified carbon paste electrode, cyclic voltammetry, square-wave stripping voltammetry, naratriptan, urine, MESOPOROUS SILICA, ELECTROCHEMICAL APPLICATIONS, OXIDATION CHEMISTRY, DIATOMACEOUS-EARTH, WASTE-WATER, THIN-FILMS, SOL-GEL, REMOVAL, VOLTAMMETRY, DYES
  • Van Yüzüncü Yıl University Affiliated: Yes


This paper is the first report describing the characterization of local diatomite of Caldiran-Van region (Eastern Anatolia, Turkey). Special attention was paid to the ability of its electroanalytical performance at modified electrodes and to the potential application of diatomite-modified electrode. For this purpose, the determination of Naratriptan which is a novel oral triptan (5-hydroxytryptamine receptor agonist) in migraine treatment, by means of a carbon paste electrode modified with 10% (w/w) of diatomite was studied using cyclic and square-wave voltammetry. The experimental conditions that affect the electrode reaction process were studied in terms of pH of the supporting electrolyte, scan rate, accumulation variables, modifier composition and square-wave parameters. Using square-wave stripping mode, the drug yielded a well-defined voltammetric response in Britton-Robinson buffer, pH 4.0 at 0.84 V (vs Ag/AgCl) (a pre-concentration step being carried out with an open circuit at 120 s). The process could be used to determine Naratriptan concentrations in the range 5x10(-7)-9x10(-7) M, with a detection limit of 1.25x10(-7) M (46.5 mu g L(-1)). The applicability of the method to spiked human urine samples was illustrated.