Antidiabetic Effect of Fig Seed Oil in Rats with Diabetes Induced by Streptozotocin

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Mert H., Mert N., Çibuk S., YILDIRIM S., Mert N.

Journal of oleo science, vol.73, no.5, pp.717-727, 2024 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 73 Issue: 5
  • Publication Date: 2024
  • Doi Number: 10.5650/jos.ess23255
  • Journal Name: Journal of oleo science
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, Chemical Abstracts Core, Compendex, Food Science & Technology Abstracts, MEDLINE, Pollution Abstracts, Veterinary Science Database, Directory of Open Access Journals
  • Page Numbers: pp.717-727
  • Keywords: diabetes, fig seed oil, glucose, histopathology, rat
  • Van Yüzüncü Yıl University Affiliated: Yes


The anti-diabetic effect of Ficus carica (Fig) seed oil was investigated. 4 groups with 6 rats in each group were used in the experiment as control, diabetes (45 mg/kg streptozotocin), fig seed oil (FSO) (6 mL/ kg/day/rat by gavage) and diabetes+FSO groups. Glucose, urea, creatinine, ALT, AST, GSH, AOPP and MDA analyses were done. Pancreatic tissues were examined histopathologically. When fig seed oil was given to the diabetic group, the blood glucose level decreased. In the diabetes+FSO group, serum urea, creatinine, AOPP, MDA levels and ALT and AST activities decreased statistically significantly compared to the diabetes group, while GSH levels increased significantly, histopathological, immunohistochemical, and immunofluorescent improvements were observed. It has been shown for the first time that FSO has positive effects on blood glucose level and pancreatic health. It can be said that the protective effect of fig seed oil on tissues may be due to its antioxidant activity.