EFFECT OF BORIC ACID AND BORAX ON HEART RATE IN RATS TREATED WITH BENZO(A)PYRENE AND 3-METHYLCHOLANTHRENE


Bulduk B. , Oto G. , Özdemir H. , Günbatar N. , Bulduk M. , Koçak Y. , ...More

Fresenius Environmental Bulletin, vol.30, no.12, pp.13433-13436, 2021 (Journal Indexed in SCI)

  • Publication Type: Article / Article
  • Volume: 30 Issue: 12
  • Publication Date: 2021
  • Title of Journal : Fresenius Environmental Bulletin
  • Page Numbers: pp.13433-13436

Abstract

 In this study, the effects of boric acid (BA) and borax (BX) on the heart rate of rats treated with benzo(a)pyrene (B(a)P) and 3-methylcholanthrene (3-MC) were investigated. This research was conducted with the permission of Van Yüzüncü Yıl University Animal Experiments Local Ethics Committee. Wistar albino rats weighing 250 ± 50 g were used in the study and divided into nine groups, six in each group. Group 1 was assigned as the control group. B(a)P (100 mg/kg) was administered intraperitoneally to Group 2 and 3-MC (100 mg/kg) to Group 3. BA only was administered to Group 4 at 300 mg/L in drinking water and to Group 5, BX only at 300 mg/L. Group 6 received B(a)P (100 mg/kg) + BA (300 mg/L) and Group 7 3-MC (100 mg/kg) + BA (300 mg/L). B(a)P (100 mg/kg) + BX (300 mg/L) was administered to Group 8 and 3-MC (100 mg/kg) + BX (300 mg/L) to Group 9. At the end of the 150th day, the rats were anaesthetised and their ECGs recorded. The heart rate (beats/min) was found to be statistically significant in B(a)P, 3-MC and groups compared to the control group. It was found that the heart rate increased by 3-MC and B(a)P in the groups was regulated by BA and BX.