Akademik Veri Yönetim Sistemi
Current Eye Research, 2026 (SCI-Expanded, Scopus)
Purpose: To evaluate the effect of acute insulin treatment on retinal layers in patients with diabetes mellitus using spectral domain optical coherence tomography (SD-OCT). Methods: This study included 44 eyes of 44 patients with diabetes. Retinal layers were measured in the macular area with SD-OCT before insulin treatment and 3 months after treatment. Retinal thickness was measured in three concentric circles and nine sectors with diameters of 1, 3, and 6 mm as specified in the Early Treatment Diabetic Retinopathy Study (ETDRS) of each retinal layer using automated segmentation. Results: There was a statistically significant increase in the central, inner 3 mm and outer 6 mm total retina (TR) and retinal pigment epithelium (RPE) thickness after treatment. There was also a statistically significant increase in thickness in the inner 3 mm and outer 6 mm subfields of outer nuclear layer (ONL). Furthermore, statistically significant thickening was observed in the inner retinal layer (IRL) outer subfield as well as the outer retinal layer (ORL) central and inner subfields after treatment. Conclusions: Insulin therapy may increase macular thickness in the acute phase, potentially worsening diabetic retinopathy.